This policy setting turns off Windows Defender. If you enable this policy setting Windows Defender does not run and computers are not scanned for malware or other potentially unwanted software. If you disable or do not configure this policy setting by default Windows Defender runs and computers are scanned for malware and other potentially unwanted software.
Turn off Windows Defender
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HKEY_LOCAL_MACHINE -> Software -> Policies -> Microsoft -> Windows Defender # DisableAntiSpyware
Windows Components -> Windows Defender