This setting turns off Microsoft Peer-to-Peer Networking Services in its entirety and will cause all dependent applications to stop working. Peer-to-Peer protocols allow for applications in the areas of RTC collaboration content distribution and distributed processing. If you enable this setting peer-to-peer protocols will be turned off. If you disable this setting or do not configure it the peer-to-peer protocols will be turned on.
Turn off Microsoft Peer-to-Peer Networking Services
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HKEY_LOCAL_MACHINE -> Software -> policies -> Microsoft -> Peernet # Disabled
Network -> Microsoft Peer-to-Peer Networking Services