This policy setting allows you to configure scanning for packed executables. It is recommended that this type of scanning remain enabled. If you enable or do not configure this setting packed executables will be scanned. If you disable this setting packed executables will not be scanned.
Scan packed executables
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HKEY_LOCAL_MACHINE -> Software -> Policies -> Microsoft -> Windows Defender -> Scan # DisablePackedExeScanning
Windows Components -> Windows Defender -> Scan