This policy setting configures a local override for the configuration of scanning for all downloaded files and attachments. This setting can only be set by Group Policy. If you enable this setting the local preference setting will take priority over Group Policy. If you disable or do not configure this setting Group Policy will take priority over the local preference setting.
Configure local setting override for scanning all downloaded files and attachments
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HKEY_LOCAL_MACHINE -> Software -> Policies -> Microsoft -> Windows Defender -> Real-Time Protection # LocalSettingOverrideDisableIOAVProtection
Windows Components -> Windows Defender -> Real-time Protection