This policy setting allows you to manage whether a check for new virus and spyware definitions will occur immediately after service startup. If you enable this setting a check for new definitions will occur after service startup. If you disable this setting or do not configure this setting a check for new definitions will not occur after service startup.
Check for the latest virus and spyware definitions on startup
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HKEY_LOCAL_MACHINE -> Software -> Policies -> Microsoft -> Windows Defender -> Signature Updates # UpdateOnStartUp
Windows Components -> Windows Defender -> Signature Updates